Spectral Representation Learning for Conditional Moment Models

Many problems in causal inference and economics can be formulated in the framework of conditional moment models, which characterize the target function through a collection of conditional moment restrictions. For nonparametric conditional moment models, efficient estimation often relies on preimposed conditions on various measures of ill-posedness of the hypothesis space, which are hard to validate when flexible models are used. In this work, we address this issue by proposing a procedure that automatically learns representations with controlled measures of ill-posedness. Our method approximates a linear representation defined by the spectral decomposition of a conditional expectation operator, which can be used for kernelized estimators and is known to facilitate minimax optimal estimation in certain settings. We show this representation can be efficiently estimated from data, and establish L2 consistency for the resulting estimator. We evaluate the proposed method on proximal causal inference tasks, exhibiting promising performance on high-dimensional, semi-synthetic data

LATR: 3D Lane Detection from Monocular Images with Transformer

3D lane detection from monocular images is a fundamental yet challenging task in autonomous driving. Recent advances primarily rely on structural 3D surrogates (e.g., bird's eye view) built from front-view image features and camera parameters. However, the depth ambiguity in monocular images inevitably causes misalignment between the constructed surrogate feature map and the original image, posing a great challenge for accurate lane detection. To address the above issue, we present a novel LATR model, an end-to-end 3D lane detector that uses 3D-aware front-view features without transformed view representation. Specifically, LATR detects 3D lanes via cross-attention based on query and key-value pairs, constructed using our lane-aware query generator and dynamic 3D ground positional embedding. On the one hand, each query is generated based on 2D lane-aware features and adopts a hybrid embedding to enhance lane information. On the other hand, 3D space information is injected as positional embedding from an iteratively-updated 3D ground plane. LATR outperforms previous state-of-the-art methods on both synthetic Apollo, realistic OpenLane and ONCE-3DLanes by large margins (e.g., 11.4 gain in terms of F1 score on OpenLane). Code will be released at https://github.com/JMoonr/LATR .Comment: Accepted by ICCV2023 (Oral

M^2-3DLaneNet: Multi-Modal 3D Lane Detection

Estimating accurate lane lines in 3D space remains challenging due to their sparse and slim nature. In this work, we propose the M^2-3DLaneNet, a Multi-Modal framework for effective 3D lane detection. Aiming at integrating complementary information from multi-sensors, M^2-3DLaneNet first extracts multi-modal features with modal-specific backbones, then fuses them in a unified Bird's-Eye View (BEV) space. Specifically, our method consists of two core components. 1) To achieve accurate 2D-3D mapping, we propose the top-down BEV generation. Within it, a Line-Restricted Deform-Attention (LRDA) module is utilized to effectively enhance image features in a top-down manner, fully capturing the slenderness features of lanes. After that, it casts the 2D pyramidal features into 3D space using depth-aware lifting and generates BEV features through pillarization. 2) We further propose the bottom-up BEV fusion, which aggregates multi-modal features through multi-scale cascaded attention, integrating complementary information from camera and LiDAR sensors. Sufficient experiments demonstrate the effectiveness of M^2-3DLaneNet, which outperforms previous state-of-the-art methods by a large margin, i.e., 12.1% F1-score improvement on OpenLane dataset

Dual-Drug Loaded Separable Microneedles for Efficient Rheumatoid Arthritis Therapy

Although the inhibitors of the interleukin-6 receptor (IL-6R) and tumor necrosis factor-α (TNF-α) have achieved a certain success in the clinical treatment of rheumatoid arthritis (RA), great effort should be made to overcome side effects and to improve patient compliance. The present research aimed to address these problems by the co-delivery of tocilizumab (TCZ)—an inhibitor of IL-6R—and an aptamer Apt1-67, which specifically inhibits TNF receptor 1 via separable microneedles (MN). MN were featured with a sustained release of TCZ from needle tips and a rapid release of Apt1-67 from needle bodies by using methacrylate groups grafted hyaluronic acid as the fillings of needle tips and polyvinyl alcohol/polyvinyl pyrrolidone as the fillings of needle bodies. Our results demonstrated that TCZ and Apt1-67 were distributed in MN as expected, and they could be released to the surroundings in the skin. In vivo studies revealed that combined medication via MN (TCZ/Apt1-67@MN) was superior to MN loaded with a single drug. Compared with subcutaneous injection, TCZ/Apt1-67@MN was of great advantage in inhibiting bone erosion and alleviating symptoms of CIA mice. This study not only provides a novel approach for combined medication with different release properties but also supplies a strategy for improving drug efficacy